MetabQuest specializes on fast, reliable, low-cost metabolite identification (MetID) contract research.
Most ADME CRO’s state that they have “integrated” ADME research capability so they can do “MetID”; While the truth is that MetID research is very often far beyond their routine (generic), high throughput (96-well-based), quantitative research capabilities.
Instrumentation Limitation: triple quatrupole mass specs
- best at quantitative analysis (high throughput assays);
- only 1 degree of fragmentation (ms2, ms3 the most);
- low resolution mass (e.g. [MH+]observed=473.17);
- no complimentary structure ID techniques.
Expertise Limitation: non-chemistry personnel
- limited training on biotransformation and structural elucidation;
- limited experience on regular and reactive metaboite ID;
- often only provides mass spectra; structure ID relies on software. 		Instrumentation Advantages: state-of-the-art ion trap mass specs
- best at qualitative analysis (structural elucidation);
- multiple degrees of fragmentation (ms2-ms10);
- high resolution mass (e.g. [MH+]observed=473.1060, +2 ppm);
- wide range of complimentary techniques.
Expertise Advantages: organic/medicinal chemistry Ph.D.’s
- extensive training on biotransformation and structural elucidation;
- over 200 studies have been accomplished;
- full structure ID and biotransformation mechanism elucidation.
ADME CRO’s MetabQuest
Slow Turnaround: 2 weeks to 2 months; 　　　　　　　　　High Cost;
Ambiguous Data and Reports;　 　　No Chemist-to-chemist Interactions. 		Fast Turnaround: 1-5 days;　　　　　　　　　　　　　　 Low Cost;
Definitive Data and Detailed Reports;　 Extra ADME-MedChem Consulting.
"MetID" Is An In-depth Chemistry Research,
Not An Assay with Generic and "Validated" Protocol.
MetabQuest has stringent protection for intellectual properties.
- Download "Research Brochure” (pdf) for more information;
- Download "MetID and BARA Sample Reports” (pdf) for more information;
- To initiate a MetID or BARA contract research, please download the "Research Request Form” (doc), fill it, and send back to us:
[email] info@metabquest.com or [fax] +86 (10) 6275 2632.
  • Test systems: liver microsomes, S9, cytosol, and hepatocytes.
  • Full structural elucidation of each metabolite.
  • Comprehensive techniques: LC-MS/MS analysis, on-line H-D exchange experiment, pre-column chemical derivatization, scale-up and preparation of individual metabolite followed by 1D and 2D NMR analysis, chemical synthesis of metabolite standard, etc.
MetID Contract Research