ADME (Absorption, Disposition, Metabolism, and Excretion) study has become an essential part of drug discovery research, aiming to build the necessary "drug-like" properties into drug candidates with higher success probabilities in preclinical and clinical studies.
Following the wide recognition of "doing ADME in drug discovery" came up the question of "how to do discovery ADME", a true challenge that is often only partially addressed by transferring preclinical DMPK studies to discovery stages as in vitro and high throughput formats.
The Journey of An Oral Drug Candidate to Meet Its CNS Target – What Is ADME?
Doing ADME In Drug Discovery: Build In the Desired Drug-like Properties
Structure-Druggability Relationship (SDR) Along SAR Progression
From
"Doing ADME In Drug Discovery"
To
"Doing It Right"
Whereas, as provided by most of the external Contract Research Organizations (CRO's) and internal supportive departments, full panel of ADME assays, high throughput capability, and validate data, are not enough. These ADME studies often lack direct impacts on medicinal chemistry (MedChem) programs and are often misleading.
ADME Studies from Physiological Viewpoint.
At MetabQuest, we are chemistry Ph.D.'s with our focus on discovery ADME-MedChem methodology research. We provide answers to many ADME questions MedChem scientists have. We design ADME study plan based on individual MedChem program and individual chemotype. We provide ADME data analysis and refinement to accelerate MedChem progress.
ADME Studies from Chemical Viewpoint.
Do Not Risk "Just Doing ADME"